The Physiology Branch at the College of Veterinary Medicine at the University of Karbala discussed the master’s thesis tagged with Binding of Cinnapsin-1 protein, brain-derived nutrition factor and some biochemical agents with dietary hypercholesterolemia in the central nervous system in male rats by Hadeel Ghani Rafsh.
The study aimed at the effect of hypercholesterolemia in food on some vital indicators and nutrients in the brain and neurotransmitters important for the transmission of nerve signals, as well as measuring the gene expression of ARC important in learning and memory and the histological study of the brain.
The results reached by the researcher showed significant negative effects on lipid profile, BDNF and gene expression, as well as abnormal elevation of the neurotransmitter glutamate, decrease in glutathione and nitric oxide, high melanodehyde as a result of oxidative stress and negative tissue changes in brain tissue due to beta-amiulide pooling.
The study recommended the need to follow a healthy diet and reduce high cholesterol levels in food.
